Endocrine Abstracts

Introduction: Nivolumab, an anti–programmed cell death-1 (PD-1) monoclonal antibody, is a promising treatment of variety advanced malignancies. Immune checkpoint inhibitors can cause immune-related adverse events, including endocrine pathology. Destructive thyroiditis is one of the most frequently observed nivolumab-induced endocrine irAEs which associated with the presence of anti–thyroid peroxidase antibodies (TPO-Abs) and anti-thyroglobulin antibodies (Tg-Abs) pri...

Introduction: Perioperative assessment of surgical outcome in acromegaly patients is essential due to significant persistence rate even after total adenomectomy. Grade of adenoma invasiveness and basal growth hormone (GH) level in early postoperative period have been considered as important factors.Aim: The aim of our study was to evaluate the correlation between the outcomes of surgery in patients with acromegaly and the grade of adenoma invasion assess...

Introduction: Acromegaly is a chronic disorder caused by growth hormone (GH) hyperproduction which leads to significant morbidity and mortality primarily due to cardiovascular and respiratory complications. Pituitary adenoma is the main cause of GH’s hyperproduction. By current guidelines transsphenoidal surgery (TSS) is the first-line treatment in acromegaly patients.Aim: To evaluate the results of TSS in acromegaly patients 6 months after surgery....

Introduction: Persistence after transsphenoidal surgery remain a significant challenge in management of acromegaly. Value of basal growth hormone (GH) evaluation in early postoperative period as marker of acromegaly persistence has been proposed and discussed in the literature, but is not widely used in clinical practice.Aim: The goal of our study is to specify the value of basal GH level measurement 24 hours later after transsphenoidal surgery as postop...

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). However, persistence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) and pituitary magnetic resonance imaging (MRI) in the prognosis of CD remission after TSS.Ma...

Purpose: Inferior petrosal sinus sampling (IPSS) is considered the gold standard test for the differential diagnosis of ACTH-dependent Cushing’s syndrome, but false-negative results have been reported in 1–10% cases. Cavernous sinus sampling (CSS) was suggested as a diagnostic tool in a complex ACTH-dependent Cushing’s syndrome cases.Aim: To study the role of bilateral combined cavernous and inferior petrosal sinus samplin...